Community Factors associated with pulmonary mycosis in patients with symptoms of chronic respiratory disease in Alto Huallaga
DOI:
https://doi.org/10.32776/saludybienestarsoc.v6i1.117Keywords:
Fungal Lung Diseases, Histoplasmosi, Aspergillosis, Respiratory Disorders, Epidemiological FactorsAbstract
Objective. Identify the factors associated with pulmonary mycosis prevalent in patients with symptoms of chronic respiratory illness in Alto Huallaga, Perú. Materials and methods. A study of cases and controls was designed which included 168 patients. The cases (52) included patients with low chronic respiratory illnesses and positive immune diffusion for Histoplasma capsulatum and/or Paraccocidiodes brasiliensis and/or Aspergillus sp treated in the health facilities of the Ministry of Health and Social Insurance controls patients with negative immune diffusion (116). The sociodemographic and economic factors were analyzed. Results. The results identified 52 cases (15 Histoplasma capsulatum and 37 Aspergillosis sp). Found an association with the factors of origin (rural area) (p < 0.01), economic income (< 500 soles) (p < 0.01), visit to the lechuzas cueva (p < 0.01) and basic agriculture (p < 0.01). The logistic regression found association with rural origin [OR = 25.2; 95%CI (9.7-65)] (p < 0.01 y time to visit the cueva [OR 6.1; 95%CI (2.3-16.1)] (p < 0.01). Conclusions. Concluding that patients with low chronic respiratory diseases who come from the countryside and who have visited the cueva de las lechuzas present a greater risk of suffering pulmonary mycosis in the area of ??Alto Huallaga.
References
Gómez, W;, Guevara, M; Cortegana, C; Obregon, P; Motta, J; Antholveg, N. Seroprevalencia de micosis pulmonares en pacientes con sintomatología de enfermedad respiratoria crónica baja: Alto Huallaga, Perú 2008. An. Fac. med. [Internet]. 2008 Jun [citado 2021 Nov 01] ; 67( 2 ): 134-141. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1025-55832006000200006&lng=es.
Loulergue P, Bastides F, Baudouin V, Chandenier J, Mariani-Kurkdjian P, Dupont B, et al. Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients. Emerg Infect Dis. 2007;13:1647-52. https://www.sciencedirect.com/science/article/pii/S0304541214708674.
Curbelo J, et al. Actualización sobre Aspergillus, Pneumocystis y otras micosis pulmonares oportunistas. Arch Bronconeumol. 2015. http://dx.doi.org/10.1016/j.arbres.2015.02.010
Espinoza Pérez, J.; Agüero Balbín, R.; Martínez Meñaca, A.; Ciorba, C.; Mora Cuesta, V. Micosis pulmonares. Medicine - Programa de Formación Médica Continuada Acreditado, 2014. 11(66), 3949–3962. doi:10.1016/S0304-5412(14)70867-4. https://www.sciencedirect.com/science/article/pii/S0304541214708674
Garnacho-Montero J, Olaechea P, Alvarez-Lerma F, Alvarez-Rocha L, BlanquerJ, Galván B, et al. Epidemiology, diagnosis and treatment of fungal respiratoryinfections in the critically ill patient. Rev Esp Quimioter. 2013;26:173–88.
Tunnicliffe G, Schomberg L, Walsh S, Brendan T, Harrison T, Chua F. Air-way and parenchymal manifestations of pulmonary aspergillosis. Respir Med.2013;107:1113–23. https://seq.es/wp-content/uploads/2016/12/olaechea.pdf.
Smith JA, Kauffman CA. Pulmonary fungal infections. Respirology.2012;17:913–26. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1440-1843.2012.02150.x.
Patterson TF, Thompson GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, et al. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016; 63:e1-e60. https://academic.oup.com/cid/article/63/4/e1/2595039?login=true.
Limper AH, Knox KS, Sarosi GA, Ampel NM, Bennett JE, Catanzaro A, et al.An official American Thoracic Society Statement: Treatment of fungal infec-tions in adult pulmonary and critical care patients. Am J Respir Crit Care Med.2011;183:96–128. https://doi.org/10.1164/rccm.2008-740ST.
Denning DW, Cadranel J, Beigelman-Aubry C, Ader F, Chakrabarti A, Blot S, et al. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management. Eur Respir J. 2016;47(1):45-68. doi:10.1183/13993003.00583-2015.
Sartori A, Souza A, Zanon M, Irion K, Marchiori E, Watte G, Hochhegger B. Performance of magnetic resonance imaging in pulmonary fungal disease compared to high-resolution computed tomography. Mycoses. 2017;60(4):266-72. doi: 10.1111/myc.12594. Epub 2017 Jan 9
Tanaka S, Kobayashi R, Nagita H, Okamoto K, Iida Y, Hongo K, et al. A case of pulmonary histoplasmosis diagnosed after lung lobectomy. Surg Case Rep. 2018; 4(1):145. doi: 10.1186/s40792- 018-0554-9.
Dourojeanni MJ, Tovar A. Notas sobre el ecosistema y la conservación de la Cueva de las Lechuzas, Parque Nacional de Tingo María, Perú. Rev Forestal Perú (Lima). 1972; 5: 28-45.
STROBE Statement. [Consultado el 12 de enero del 2019]. Disponible en: https://www.strobe- statement.org/index.php?id=available-checklists
García J, Pemán J. Microbiological diagnosis of invasive mycosis. Rev Iberoam Micol. 2018;35(4):179- 85. doi: 10.1016/j.riam.2018.05.003. Epub 2018 Nov 22.
Hage CA, Azar MM, Bahr N, Loyd J, Wheat LJ. Histoplasmosis: Up-to-Date Evidence-Based Approach to Diagnosis and Management. Semin Respir Crit Care Med. 2015;36(5):729-45. doi: 10.1055/s-0035- 1562899. Epub 2015 Sep 23.
Di Mango AL, Zanetti G, Penha D, Menna-Barreto M, Marchiori E. Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging. Expert Rev Respir Med. 2019. doi: 10.1080/17476348.2019.1571914. https://doi.org/10.1080/17476348.2019.1571914.
Loulergue P, Bastides F, Baudouin V, Chandenier J, Mariani-Kurkdjian P, Dupont B, et al. Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients. Emerg Infect Dis. 2007;13:1647-52. https://www.sciencedirect.com/science/article/pii/S0304541214708674.




